Depression and Culture in the TOP DD Network Study: Assessing Depressive Symptoms, Self-harm, and Hospitalization among Dissociative Patients across Four Cultures

Citation: Webermann AR, Brand BL, Schielke HJ, Kumar SA, Myrick AC (2017) Depression and Culture in the TOP DD Network Study: Assessing Depressive Symptoms, Self-harm, and Hospitalization among Dissociative Patients across Four Cultures. Acta Psychopathol Vol. 3 No. S1: 39. Introduction Depression and culture in the TOP DD network study: Assessing depressive symptoms, selfharm, and hospitalization among dissociative patients across four cultures


Introduction
Depression and culture in the TOP DD network study: Assessing depressive symptoms, selfharm, and hospitalization among dissociative patients across four cultures Depressive symptoms, Non-suicidal Self-injury (NSSI), and suicide attempts are common among individuals with severe dissociative symptoms and Dissociative Disorders (DDs). These difficulties are particularly severe among individuals with complex DDs including dissociative identity disorder (DID) and DD not otherwise specified/other-specified DD (DDNOS/OSDD). The prevalence of DID is estimated at 1% of community samples and up to 12% of psychiatric inpatients across multiple countries (Norway, Finland, Switzerland, Turkey, Germany, Netherlands, Canada, United States, and China) [1]. A recent study by Chiu et al. [2] identified 19.5% of an inpatient sample in Taiwan as meeting criteria for a DD, a prevalence rate comparable to studies conducted with Western inpatient samples. Their findings led them to conclude that DDs present similarly across Eastern and Western societies, including having complex symptom patterns and extensive histories of interpersonal trauma.

Patient NSSI, suicide attempts, and hospitalizations
Therapists were asked about their patient's history of suicide attempts, self-harm, and hospitalizations. Items queried their patients' number of lifetime, last year, and last six-month suicide attempts; number of self-harm incidents over the last six-months; number of lifetime and last six month psychiatric hospitalizations; and number of inpatient days in the last 6 months.

Depressive symptoms
Patients completed two measures at the screening survey which gauged the frequency of depressive symptoms, including the 10-item major depressive episode subscale of the Perceived Causal Relations Scale (PCR; [18,19]) and the DSM-5 Cross-Cutting Symptom Measure for Adults (CCSM; [17]). The PCR is a validated measure of patients' attributions regarding the causes and interrelations between their psychiatric symptoms [18]. For the present study, we examined patient responses to the 10-item Major Depressive Episode (MDE) symptom scale. The CCSM is an emerging measure included in the DSM-5. We examined patients' responses to the two depression domain items, which assess loss of pleasure and interest in daily activities and depressed mood.

Depressive disorders
Therapists were asked on the screening survey if their patients were diagnosed with comorbid depressive disorders, including Disruptive Mood Dysregulation Disorder (DMDD), major depressive disorder, persistent depressive disorder (dysthymia), premenstrual dysphoric disorder, and "other depressive disorder," which are the depressive disorders included in the DSM-5 [17].

Analyses
The Kruskal-Wallis H Test, a Multivariate Analysis of Variance (MANOVA), and chi-square tests of association were used to assess differences in depressive symptoms and related behavior in participants across four cultures. Kruskal-Wallis was used for patient NSSI, suicide attempts, and hospitalizations because the variables were significantly skewed and kurtotic given the wide range of patient NSSI, suicidality, and hospitalization days. MANOVA was used to assess differences in three depressive symptom measures (the PCR major depressive episode subscale, and two CCSM items) across an independent variable (country) with four levels (Norway, U.S, Australia, and Canada). Chi-square tests of association were used to gauge association between two categorical variables: absence or presence of depressive disorder, and country (U.S, Australia, and Canada; Norway was excluded since it does not use the DSM-5 for diagnoses). The Bonferroni corrected critical α for multiple hypothesis testing=0.003.

Results
Correlations were run to assess associations between patient age, gender, and the study outcomes, and all were non-significant at p<0.003.
those with a DD were 15 times more likely have made multiple suicide attempts, compared to those with borderline personality disorder, posttraumatic stress disorder, or child abuse histories [4]. The authors concluded, "Dissociative disorders are commonly overlooked in studies of suicidality, but in this population they were the strongest predictor of multiple suicide attempter status." A study of outpatient individuals with DDs found depressive symptoms predicted which patients engaged in NSSI, while dissociative symptoms predicted which patients engaged in either NSSI and/or made suicide attempts [16]. Almost all of these studies have been conducted in the United States. This research indicates the importance of learning more about depression, suicidality, and NSSI among DDs across different cultures.

The Present Study
The present study assessed depressive symptoms and related behavior among DD community outpatients from the United States (U.S), Canada, Australia, and Norway. Depressive disorders (diagnosed using the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders [DSM-5] [17]), depressive symptoms, number of suicide attempts in the patient's lifetime and recent history, number of self-harm incidents in the patient's recent history, and lifetime and recent psychiatric hospitalizations were examined among participants using both patient and therapist reports. We hypothesized differences in hospitalization given differences in healthcare systems and utilization, with U.S. participants having fewer inpatient days than other countries. In addition, we hypothesized there would be no other differences in depressive symptoms and related behavior among DD patients across cultures, supporting the notion that complex trauma and dissociation has a similar impact regardless of culture.

Participants
DD patients and clinicians were recruited through the Treatment of Patients with Dissociative Disorders (TOP DD) Network study, an online longitudinal educational intervention study of patients with DDs who were diagnosed with either DID or DD not otherwise specified/other-specified DD (DDNOS/OSDD). Both the patient and clinician providing individual psychotherapy to the patient were required to enroll together to ensure that all patients had professional assistance in case of crisis. Data were derived from the screening survey, which determined eligibility to enroll in the study, and the baseline survey that was completed within days of being enrolled in the study. The sample size for the screening survey was N=265 and for the baseline survey was N=237 (some potential participants did not meet eligibility criteria; others decided not to enroll after completing the screen). The TOP DD Network study included participants from 16 countries, with the largest number of participants from the U.S. (42.3%, N=112), Norway (27.5%, N=73), Canada (6.4%, N=17), and Australia (6.4%, N=17). Patient participants were primarily cisgender female (88.6%), Caucasian (82.1%), middle-aged (Median=41), and highly educated (50.9% had at least a college diploma). Patients were primarily diagnosed with DID (63.4%) ( Table 1). There were no significant differences across cultures in the number of days of hospitalization in the prior six months (p<0.01), lifetime suicide attempts (p<0.05), last year suicide attempts (p<0.05), suicide attempts in the prior six months (p=0.14), or self-harm in the prior six months (p=0.55).

Depressive symptoms and disorders
There was not a significant difference in depressive symptoms (as assessed by the PCR and CCSR) across cultures (p=0.34). Additionally, there was not a significant relationship between the three cultures (Australia, U.S, and Canada) and DMDD (p=0.56), major depressive disorder (p=0.72), persistent depressive disorder (dysthymia; p=0.30), premenstrual dysphoric disorder (p=0.56), and other depressive disorder (p=0.34).

Discussion
The present study assessed depressive symptoms and behaviors in DD patients receiving outpatient treatment across the U.S, Australia, Canada, and Norway. As hypothesized, the only significant differences were in psychiatric hospitalizations, with American and Canadian patients consistently demonstrating significantly fewer psychiatric lifetime and last six-month hospitalizations compared to Norwegian and Australian DD patients. Differences in suicide attempts were not found after applying Bonferroni alpha corrections. There were no cross-cultural differences in NSSI, depressive symptoms, or types of depressive disorders. Our findings regarding rates of hospitalization are likely due to cross-cultural differences in health care utilization and systems, rather than to phenomenology related to depression. The lack of cross-cultural differences in individuals with DDs may also suggest that trauma and dissociation have a consistent link with depressive symptomatology, independent of culture. Consistent with the findings of the present study, dissociation has been linked to NSSI, depression and suicidality in among DDs and in non-DD clinical populations across many cultures and countries. Greater suicidality has also been found among DD patients in the U.S, Turkey and the Netherlands, among others [4,7,20]. In a general population study conducted in Finland, Maaranen et al. [21] found that dissociation was nine-fold more likely among depressive individuals and more than four-fold higher among suicidal individuals than among individuals who were not high in dissociation. Suicidality was independently associated with dissociation, even after adjusting for covariates including depression. In a three-year follow up [22], the individuals who were high in dissociation at both time points showed an increase in depression and suicidal ideation over time. Those who were not initially high in dissociation but became high at follow-up evidenced an increase in depressive symptoms whereas recovery from high dissociation was associated with improvement in depression. In a 10-year prospective study of U.S. patients with borderline personality disorder, the severity of dissociation and a diagnosis of major depression were among six out of 11 predictors that predicted self-harm [23]. Future research should investigate other factors which relate to suicidality in clinical populations to gauge their relevance with dissociative patients, such as sleep disturbances and a family history of suicidality [24][25][26].
An implication of the present study is that dissociation generally, as well as DDs in particular, are strongly linked with depression, NSSI, and suicidality; however, dissociation and DDs remain underrecognized and under-treated [4,7,10,27]. 2.6 (8) Note: 1 Other countries in the sample included Romania (n = 2), and one participant each from Belgium, Ireland, Israel, Lithuania, New Zealand, and Spain.

Conclusion
The study's most notable limitation was that sample sizes in many countries were too small to be included in the analyses. Additionally, there were no participants from Africa and very few from Asia, limiting the geographic generalizability of our conclusions. Overall, the finding of a lack of cross-cultural differences in depression-related symptomatology in individuals with DDs suggests that dissociation, and possibly the trauma that is typically linked to dissociation, may be associated with depressive symptomatology, regardless of culture.