Cognitive changes over time and its relationship with APOE4 and modifiable risk factors in a cohort of adults from Bogotá

Low schooling, advanced age and arterial hypertension were associated with dementia in a cross-sectional study conducted between 2012-2014 in autonomous adults of Bogotá. A high prevalence of dementia of 23% was found. What is the relationship of APOE4 and modifiable risk factors in cognitive impairment over time? The purpose of this study: is to evaluate the relationship of APOE4 and modifiable risk factors in cognitive impairment over time in adults of Bogotá Methodology: A cohort study was conducted in subjects with normal cognition or with mild cognitive impairment (MCI) of the 2012-2014 study. The cognitive evaluation was done applying the protocol used in the previous study. ApoE genotyping was performed. An analysis was made for multiple correspondences and logistic regression. Findings: 118 subjects with normal cognition and 97 with MCI diagnosis from the previous evaluation were included; 73% were women, with an average age of 71(SD7.3) years and schooling of 8.2 (SD5.4) years. Six percent of all subjects progressed to dementia in a follow up period of 4 (SD1) years. Remained unchanged 75% of normal subjects and 22% progressed to MCI; 65% of subjects with MCI did not change and 25% normalized. Of the patients who went from MCI to Dementia, 30% had Diabetes Mellitus; 50% hypertension, 80% schooling under 11 years and 40% were E4 carrier. The subjects that progressed versus those who did not were grouped, to be able to make a logistic regression, to determine whether or not to progress was related to being a carrier, adjusted for the risk factors; although the ORs are greater than 1, statistical significance was not reached Conclusion and Significance: Although APOE4 was not related to dementia in our previous cross- sectional study; in the cohort study, its relationship with changes especially dementia is evidenced, but with risk factors remains doubtful


Olga Lucia Pedraza

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Acta Psychopathologica received 248 citations as per google scholar report

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